Search on: NEUROTOXICITY SYNDROMES, MPTP 
Descriptors Found: 1
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Descriptor English:   MPTP Poisoning 
Descriptor Spanish:   Intoxicación por MPTP 
Descriptor Portuguese:   Intoxicação por MPTP 
Synonyms English:   MPTP Induced Degeneration of the Striatum
MPTP Induced Parkinsonism
MPTP Neurotoxicity Syndrome
MPTP Neurotoxicity Syndromes
MPTP-Induced Degeneration of the Striatum
MPTP-Induced Parkinsonism
Neurotoxicity Syndrome, MPTP
Neurotoxicity Syndromes, MPTP
Parkinsonism, MPTP-Induced
Poisoning, 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Poisoning, MPTP  
Tree Number:   C10.228.140.079.862.800.300
C10.228.662.600.700.250
C10.720.606
C25.723.705.400
Definition English:   A condition caused by the neurotoxin MPTP which causes selective destruction of nigrostriatal dopaminergic neurons. Clinical features include irreversible parkinsonian signs including rigidity and bradykinesia (PARKINSON DISEASE, SECONDARY). MPTP toxicity is also used as an animal model for the study of PARKINSON DISEASE. (Adams et al., Principles of Neurology, 6th ed, p1072; Neurology 1986 Feb;36(2):250-8) 
See Related English:   1-Methyl-4-phenylpyridinium
 
History Note English:   2000 
Allowable Qualifiers English:  
BL blood CF cerebrospinal fluid
CI chemically induced CL classification
CO complications CN congenital
DI diagnosis DG diagnostic imaging
DH diet therapy DT drug therapy
EC economics EM embryology
EN enzymology EP epidemiology
EH ethnology ET etiology
GE genetics HI history
IM immunology ME metabolism
MI microbiology MO mortality
NU nursing PS parasitology
PA pathology PP physiopathology
PC prevention & control PX psychology
RT radiotherapy RH rehabilitation
SU surgery TH therapy
UR urine VE veterinary
VI virology  
Record Number:   34225 
Unique Identifier:   D020267 

Occurrence in VHL: 		 

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